In fact, GPX3 promoter hypermethylation is linked to downregulation of GPX3 expression in different types of cancer cells and treatment with 5-Aza to human esophageal adenocarcinoma cancer cells SKGT4 [29] and human myeloma cells KMS11 [19] restores GPX3 gene expression. This evidence concerns the gene GPX3 and plasma cell myeloma.