This has been shown to be due to the ability of Blimp-1 to activate important developmental genes that Bcl-6 represses [132], however, it is not clear how early post-infection the ratio of Bcl-6 and Blimp-1 is determined, or how much it is affected by cytokines, though IL-2 has been reported to play a role in Bcl-6 transcription via STAT5 [220]. Here, PRDM1 is linked to infection.