INS and Hyperglycemia: Lastly, although it is not the focus of this review, another variable to be considered is the possibility of hypoglycemic episodes occurring within a context of hyperglycemia resulting from inappropriate insulin treatment, since it must be considered that acute [119, 120] and chronic [121–124] hyperglycemia, gestational hyperglycemia [125], and glycemic variability [126, 127] can also contribute towards the reduction of cognitive performance, since the excess of glucose can lead to brain damage regardless of the occurrence of IIH [128].