INS and type 1 diabetes mellitus: Although the majority of studies cover separately the precociousness of type 1 diabetes appearance [83–87], the occurrence of episodes of severe IIH [87] and their frequency [78], and the intensity of the hypoglycemia [85], these four factors are strongly interconnected as the early appearance of type 1 diabetes leads to an earlier introduction of insulin therapy, increasing the possibility of the IIH episodes occurring more frequently and with greater intensity.