SOST and sclerosteosis: Fig. 3D summarizes the timing of Wise and Sost expression during chondrocyte and osteoblast differentiation. These expression patterns are consistent with the late onset of increased bone density in human Sclerosteosis patients [37]. Hence, there is a strong correlation for both Wise and Sost between the timing of their osteoblast gene expression and the onset of their respective increased bone density phenotypes.