In the present study SsnB at 10 μM and above concentrations significantly inhibits the growth and viability of human neuroblastoma cells of different genetic background such as N-myc amplified with wild p53 cells (IMR-32 and NGP cells), N-myc amplified with mutated p53 cells (SKN-BE(2) cell), and N-myc nonamplified cell (SH-SY5Y and SKNF-1 cells). This evidence concerns the gene TP53 and neuroblastoma.