LGALS1 and neoplasm: As MCF-7 cells express several members of the galectin family, including Gal-1, -3 and -8 [36], and GPIIb/IIIa and GPIb are essential for transducing galectin signaling [20], [22], platelet activation mediated by galectins could have evolved as a mechanism complementary to ADP to promote a tumor proangiogenic phenotype.