Initial genetic analyses demonstrated that genes for cytoskeletal proteins are involved in DCM, but subsequent studies revealed that mutations of cardiac sarcomeric proteins, such as TnT, TnI, TnC, actin, myosin-binding protein C, α-tropomyosin, and β-myosin heavy chain, are also involved in DCM (see [16] and references therein). The gene discussed is TNC; the disease is familial dilated cardiomyopathy.