The CS model had the greatest gene expression related to innate inflammatory pathways one day after sepsis with activation of pathways related to the role of pattern recognition receptors (PRRs), Il-1, Il-6, Nfkb, and Hmgb1 signaling, chemokine signing, TLR signaling, and the acute phase response (Figure 5). This evidence concerns the gene HMGB1 and Sepsis.