Experimental colitis had similar effects on the level of BDNF in the urinary bladder which was also up-regulated by 5-fold in rats in proestrus (from 8.4±3.9 pg/ml to 43.8±15.6 pg/ml, p≤0.05 to control) but not in diestrus when compared with respective control groups (Fig. 4B). The gene discussed is BDNF; the disease is colitis.