OPN1SW and hepatocellular carcinoma: Over the past few years, we defined that a high prevalence of the HBV C1 genotype [18], pre-S deletion and pre-S2 start codon mutation [19], C1653T, T1753A/G, C1766T, and T1768A mutations in the BCP/EnhII region [20], [21], and A2159G, A2189C, and G2203W in the core gene [5] are associated with HCC in Qidong.