IL4 and colitis: Several studies have recently demonstrated that Trichinella secreted proteins or infection itself are able to induce a strong Th2/Treg response and the production of Th2/immunoregulation cytokines, e.g., IL-4, IL-5, IL-10, IL-13, and TGF-β [29], [32], [35], [36], [37], which are associated with the amelioration of autoimmune diseases such as colitis [38], [39], allergic airway inflammation [40], [41], Type I diabetes [42] and autoimmune encephalomyelitis [43].