VEGFA and neoplasm: As expected, patients with high NPAA were more likely to exhibit aggressive clinical pathological features: high NPAA was significantly correlated with poor tumor differentiation (P = 0.004), pathologic stage (P<0.001), pathologic T-factor (P<0.001) and pathologic N-factor (P<0.001), whereas high platelet-derived VEGF was significantly correlated with poor tumor differentiation (P<0.001) and pathologic stage (P<0.001) (Table 2).