MICA and infection: As the block deletion mutants were made on a ΔUL16ΔUL18 background, the parental HCMV control up regulated MICB and ULBP2 relative to mock-infected cells (Fig. 2C, Fig. S4B), whereas the ΔUS18–22 mutant up regulated cell surface levels of MICA (Fig. 2C, Fig. S4B) relative to both mock- and parental HCMV-infections.