VDR and early-onset autosomal dominant Alzheimer disease: These were i) rs6590322 that has been associated with Alzheimer's disease [39] and is located in the spacer of a DR3 motif of a VDR loci some 250 kb downstream of the TSS of gene for the transcription factor ETS1, and ii) rs10174949 that is related to allergies [40] and is found in the third position of the second half-site of the VDR binding site located 26 kb downstream of the TSS of the long non-coding RNA 299 gene.