In malaria, induction of the immunoregulatory cytokine interleukin-10 (IL-10) has been shown to prevent excessive and potentially fatal pathology in murine models of cerebral malaria [21]–[24], and this important role of IL-10 has been corroborated by observational data from malaria patients [25]–[28]. This evidence concerns the gene IL10 and cerebral malaria.