The improved control of systemic S. Typhimurium infection in the conditionally IL-10R-deficient mice did not appear to be an indirect effect of reduced parasitemia, since at day 14 post P. yoelii infection, no significant difference in parasitemia was observed between the LysM-cre+/− and the LysM-cre−/− control groups (Fig. 5C). Here, IL10RA is linked to parasitic infectious disease.