This observation is in accordance with our present finding that the positive rate of serum moth-specific IgE was 49.14% among allergic patients, suggesting that silkworm moth is an important inhalant insect allergen in Guangzhou area and the sensitization to silkworm moth may be closely related to allergic diseases, such as allergic asthma and allergic rhinitis. This evidence concerns the gene IGHE and allergic rhinitis.