In an orthotopic mouse model for human neuroblastoma metastases (Mhh-NB11 and SH-SY5Y), Maman et al131 showed that lung-derived factors significantly reduced the viability of micro-NB cells by upregulating the expression of pro-apoptotic genes, inducing cell cycle arrest and decreasing ERK and FAK phosphorylation. Here, PTK2 is linked to neuroblastoma.