Remarkably, elevated levels of ZAG, as well as TNFα and IL-6, did not induce depletion of adipose tissue in Lewis lung carcinoma–bearing mice lacking adipose tissue triglyceride lipase (ATGL), pointing to a central role of ATGL in the pathogenesis of CAC.72 This evidence concerns the gene PNPLA2 and Carcinoma, Lewis Lung.