PCLAF and cancer: However, cancer cells do not solely rely on de novo lipogenesis but also use exogenous FA for membrane synthesis and for the synthesis of oncogenic signalling lipids such as ceramide-1-phosphate (C1P), platelet-activating factor (PAF), diacylglycerol (DAG), and lysophosphatidic acid (LPA).42, 43, 44 Using an isotopic fatty acid labeling strategy coupled with metabolomic profiling, Louie et al demonstrate that cancer cells also use exogenous fatty acids such as palmitic acid to generate lipids required for proliferation and pro-tumorigenic lipid signaling.45