AKT1 and neuroblastoma: Using neuroblastoma cells (SH-SY5Y and SK-N-BE) Navratilova et al demonstrated that tetrathiomolybdate (TMD), a drug that exhibits anti-angiogenic and tumor-suppressing effects increased glucose uptake, production of lactate, and activation of Akt and AMPK signaling pathways as angiogenic “escape strategies” of NB cells under low glucose conditions.125