Inactivation of GSK-3β and downregulation of ΔNp63 by wogonin enhances apoptosis effect in human nasopharyngeal carcinoma cells through [16].Wogonin inhibits tumor angiogenesis via degradation of HIF-1α protein in four human tumor cell lines, including MCF-7, MDA-MB-231, HepG2, and HCT116 [17]. This evidence concerns the gene GSK3B and neoplasm.