Since a role of Gαq-mediated signaling in working memory has previously been proposed10, 11, 12, we asked whether the cognitive deficits found in IMS mice are functionally linked to the epigenetic phenotype that increases Gαq expression and, if so, whether these deficits are also transmitted to the F2 progeny of IMS Balb/c mothers. This evidence concerns the gene GNAQ and Cognitive impairment.