Although Nde1 is involved in epilepsy, and adult hippocampal neurogenesis is up-regulated in rodent epilepsy models (Bengzon et al., 1997; Parent et al., 1997; Jessberger et al., 2007) and after antidepressant treatment (Malberg et al., 2000; Reif et al., 2006), the roles of Nde1 in these processes are less intensively investigated and therefore remains unclear. Here, NDE1 is linked to epilepsy.