Moreover, recent reports demonstrated a level of hypermethylation in IPMN (e.g., p16/CDKN2A, cyclin-dependent kinase inhibitor 1C (CDKN1C), SRY- (sex determining region Y-) box 17 (SOX17)). Here, CDKN1C is linked to pancreatic intraductal papillary-mucinous neoplasm.