HS3ST1 and hepatocellular carcinoma: Expression of nine HS-modifying enzymes (HPSE, 2OST1, 3OST1, 3OST3B, 6OST1, NDST1 and 2, Sulf1 and 2) was heterogeneously changed in human fibrogenic diseases and hepatocellular carcinoma, with intensified expression of several HS-modifying enzymes (NDST1 and -2, 3OST1, Sulf1) in pathological tissues (32).