IGFBP3 and ovarian cancer: Other silenced genes in ovarian cancer include Ras-association domain gene family 1A (RASSF1A), lost on transformation 1 (LOT1), death-associated protein kinase (DAPK), target of methylation-induced silencing (TMS1)/apoptosis speck-like protein containing a CARD (ASC) (34–37), and insulin-like growth factor binding protein (IGFBP-3) (38).