In summary, when TAMs are attracted to the hypoxic areas of tumor site, they produce a large body of pro-angiogenic factors in addition to angiogenesis-modulating enzymes, under the regulation of specific signaling pathways (i.e., NF-κB and mTOR) and transcription factors (i.e., HIFs and Stat3), which contribute to tumor angiogenesis. The gene discussed is STAT3; the disease is neoplasm.