Therefore, we evaluated the presence of HPV infection (serotypes 16/18 and 31/33) in samples of squamous cell carcinoma of the oropharynx and analyzed the expression, through immunofluorescence (IF), of p16, p53, ANXA1 and two phosphorylated forms of ANXA1 (at specific serine and tyrosine residues). The gene discussed is ANXA1; the disease is squamous cell carcinoma.