In regard to nonalcoholic fatty liver diseases, the hepatic expression of the metabolic syndrome, M. Sharif et al. conducted a thorough analysis of previously published data about the steatogenic role of PPARγ and summarized two probable PPARγ ligand-dependent toxicological modes of action: (i) activation of PPARγ in hepatocytes and (ii) inhibition in adipocytes. The gene discussed is PPARG; the disease is metabolic dysfunction-associated steatotic liver disease.