Supporting the notion that SAMHD1's influence on infection may be more complex, it has been suggested that SAMHD1 interacts with nucleic acids, specifically ssRNA and ssDNA (Goncalves et al., 2012; Tungler et al., 2013) and that it possesses a nuclease activity (Beloglazova et al., 2013). Here, SAMHD1 is linked to infection.