SAMHD1 and infection: In addition, Q76A Vpx mutant was still able to substantially rescue IFN-treated MDDC infection (Pertel et al., 2011; Reinhard et al., 2014), although it was unable to bind DCAF1 (Pertel et al., 2011) and induce SAMHD1 degradation (Hrecka et al., 2011).