TNF and Cachexia: Data arising from the study of muscle structure and function in cancer cachexia has revealed new insights into vitamin D. Cancer cachexia is a debilitating clinical syndrome which causes up to 30% of cancer related deaths by either immobility, respiratory and/or cardiac failure (Fearon, 2008) and is characterized by weight loss; up-regulation of inflammatory markers such as IL-6, IL-1, TNF-α and interferon gamma (IFN)γ; hypercalcemia; and insulin resistance (Argiles et al., 2003; Sato et al., 2003; Jackman and Kandarian, 2004; Evans et al., 2008; Tisdale, 2009; Asp et al., 2010).