BDNF and Alzheimer disease: Previous studies have reported that serum BDNF levels are reduced in AD (Gezen-Ak et al., 2013), MCI (Peng et al., 2005; Yu et al., 2008), major depression disorder, and depressive symptoms (Karege et al., 2002; Shimizu et al., 2003; Cunha et al., 2006; Terracciano et al., 2011).