Thirty years of research since the potent effects of aluminum on the genetic apparatus in AD were first described, the most recent evidence suggests a strong linkage between aluminum sulfates and induction of NF-kB-sensitive pro-inflammatory miRNAs (Lukiw et al., 1987; Alexandrov et al., 2013; Zhao et al., 2013). The gene discussed is NFKB1; the disease is Alzheimer disease.