CFH and Alzheimer disease: Aluminum has been previously shown to significantly induce the transcription factor NF-kB (Pogue et al., 2009; Bondy, 2013), and up-regulation of NF-kB drives synthesis of NF-kB-sensitive miRNAs which in turn down regulate the expression of many AD-relevant genes, including complement factor H (CFH) and neurotropic signaling in human brain cells (Pogue et al., 2009; Zhao et al., 2013).