NRG1 and Cognitive impairment: A number of Nrg1-related mutant mice have been generated to further elucidate the role of Nrg1 in the pathogenesis of schizophrenia-related behavioral and cognitive deficits (O'Tuathaigh et al., 2007; Chen et al., 2008; Ehrlichman et al., 2009; Duffy et al., 2010; Wen et al., 2010; Shamir et al., 2012).