NRG1 and schizophrenia: We also found no age-dependent effects in our novel TMc-Nrg1 mutant mice after examination at 2 and 6 months of age; this result is similar to reports that the age of onset is not associated with the NRG1 genotype in patients with schizophrenia (Kampman et al., 2004; Voineskos et al., 2009).