ABAT and Cognitive impairment: Valproate has been reported to ameliorate cognitive impairments in adult mice via demethylation of GABAergic-promotors (Tremolizzo et al., 2002, 2005; Matrisciano et al., 2013), inhibition of histone deacetylases (Phiel et al., 2001), and enhancement of central GABAergic tone that is mediated through an inhibition of GABA-transaminase (Johannessen, 2000).