TGFB1 and myeloid sarcoma: In addition to inducing differentiation and development of Tregs, TGF-β also can prolong the half-life of Foxp3 RNA species and phosphorylate chromatin-bound Foxp3 [35], and IL-6 plays a crucial role in regulating the balance between Treg cells and Th17 cells, which are involved in the pathogenesis of EAE and MS [36, 37].