IGHE and helminthiasis: Here, we test this hypothesis in schoolchildren from an area co-endemic for Schistosoma mansoni and hookworm by (1) measuring changes in specific and nonspecific histamine release (HR) in whole blood 8 weeks after concurrent praziquantel and albendazole administration to treat schistosomiasis and hookworm, respectively, and (2) examining associations between antigen-specific-IgE and antigen-specific-HR, and how these are influenced by helminth infection.