Meanwhile, although a previous study showed that promoter hypermethylation of CDH13 and CDH1 was detected in PAs but not in normal pituitary tissue, and promoter hypermethylation of CDH13 was observed more frequently in invasive PAs [11], there was no significant global methylation difference between invasive and noninvasive PAs in our study. The gene discussed is CDH1; the disease is gonorrhea.