CXCL8 and pancreatic neoplasm: Previous studies have shown that the members of the CXC chemokine subfamilies, including GRO1 (CXCL1), GRO2 (CXCL2) and IL-8 (CXCL8), are among one of the most highly up-regulated genes identified in CAFs compared with NFs in pancreatic cancer [21].