CXCL1, 2, and 8, produced primarily by mononuclear cells, macrophages and a smaller percentage of fibroblasts, endothelial cells, T and B lymphocytes, chondrocytes and amnion cells, are pleiotropic cytokines that induce tumor formation, promote tumor proliferation and facilitate tumor metastasis [30], [31]. Here, CXCL1 is linked to neoplasm.