Therefore, this study was performed (i) to assess the association of the BUD13 237 + 1741T>C (rs10790162), 323-575A>G (rs17119975), *147C>T (rs11556024), 64G>T (rs35585096) and ZNF259 1093-336G>A (rs2075290) and *365 + 359C>G (rs964184) SNPs and serum lipid levels in individuals with hypercholesterolaemia (HCH)/hypertriglyceridaemia (HTG); (ii) to evaluate the association of these SNPs and their haplotypes with the risk of HCH/HTG; and (iii) to identify the possible gene–gene interactions among these SNPs. This evidence concerns the gene ZPR1 and hypertriglyceridemia.