The promoter site of ZNF259 was bounded by the proxisome proliferator-activated receptor gamma (PPARG) 1 and 2, which play an important role in insulin sensitivity and obesity [19,20], and also bounded by the hepatocyte nuclear factor 4 alpha (HNF4α, nuclear receptor 2A1), which is known to activate a variety of genes involved in glucose, fatty acid and cholesterol metabolism in the liver, kidney, intestine and pancreas [21]. This evidence concerns the gene HNF4A and obesity due to melanocortin 4 receptor deficiency.