PRTN3 and rheumatoid arthritis: In the validation population and replication population, the associations between rs7044343 and RA, especially ACPA-negative RA, were still significant (OR = 0.763; 95% CI, 0.583 to 0.998; P = 0.048; OR = 0.547, 95% CI 0.318-0.940, P = 0.029; OR = 0.777, 95% CI 0.615 to 0.981, P = 0.034; OR = 0.559, 95% CI, 0.337 to 0.927, P = 0.024).