These findings which implicate pro-oncogenic effect of the protein and, furthermore, the fact that Ras was found is chronically activated in breast carcinoma cells that lack mutated ras [14], have motivated us to assess the expression and function of RasGRP3 in breast derived invasive ductal adenocarcinoma, a malignancy characterized by a high tendency to produce metastatic tumors [15]. This evidence concerns the gene RASGRP3 and invasive ductal breast carcinoma.