As DLC1 is often overexpressed in breast cancer [37] it is interesting to note that DAG induced DLC1–RasGRP3 interaction may act as a chaperone for nuclear translocation of RasGRP3 in breast cancer cells suggesting a mechanistic role for RasGRP3 in supporting and amplifying growth factor or Ras initiated cellular responses in breast cancer cells. The gene discussed is RASGRP3; the disease is breast cancer.