MAPT and Parkinson disease: The main findings of our study in central Chinese population include 1) All the PD patients and controls were in H1/H1 diplotype in our study, 2) GG genotype of MAPT rs242562 serves protection effect on PD risk in central Chinese population, 3) Genotype of GSK3B rs334558 showed no difference between PD patients and controls, and 4) GG genotype of rs242562 may display strong protective effect against PD risk in subgroup with GSK3B rs334558 T carrier.