In a cohort study from the National Comprehensive Cancer Network (NCCN) overall 44% of HER2-positive breast cancer patients received neoadjuvant or adjuvant trastuzumab with increasing proportions over time (8% of patients diagnosed in 2000, 66% of patients diagnosed in 2005, and 77% of patients diagnosed in 2007) [25]. Here, ERBB2 is linked to breast cancer.