FLT3 and acute myeloid leukemia: Although variation in prognostic impact of mutation type in different age groups was not reported in other studies, perhaps due to noninclusion of older patient groups, Ley et al. and Thol et al. found that DNMT3A mutations heralded a poorer prognosis in NPM1wildtype/FLT3-ITDmutated CN-AML [32, 36].