Class II mutations, such as the translocations associated with the core-binding factor (CBF) leukemias, were associated with inhibition of differentiation including key transcription factors, such as CBF and retinoic acid receptor alpha (RARα) [8, 14], and proteins that are involved in transcriptional regulation, such as p300, CBP, MOX, TIF2, and MLL [8, 14]. The gene discussed is RARA; the disease is leukemia.