The analysis of the circulating IP-10 level has shown that the level of IP-10 in hr FDRs was significantly higher compared with lr FDRs and healthy controls, and similar to the level detected in patients with R-T1D in IRS (160.12 ± 73.40 versus 105.39 ± 71.30 pg/mL P < 0.05; 160.12 ± 73.40 versus 85.24 ± 19.82 pg/mL P < 0.01; 160.12 ± 73.40 versus 141.99 ± 69.59 pg/mL, P = NS) (Figure 5). This evidence concerns the gene CXCL10 and type 1 diabetes mellitus.