On the other hand, for local factors, the model selects Moesin and Osteonectine (MOES, SPRC) that had not been picked in the first run, as well as the already selected Apolipoprotein A4 (APOA4), Byglican (HPLN1), G3P, BGH3 and Calpastatin (ICAL), all related to lesion development in model run on HF and also on HHF group data. The gene discussed is CAST; the disease is hydrops fetalis.