IGFBP2 and prostate carcinoma: Androgen-dependent regulation of IGFBP-2 mRNA expression might be established by means of the IGFBP-2 promoter specifically, as stated earlier, but also by an effect on global protein translation: unexpectedly, androgen treatment of prostate carcinoma cells for an extended period of time (48 h) downregulated the polysomal fraction of mRNA and thus global protein synthesis (57).