In pathologies such as rheumatoid arthritis, IL-18 has been shown to promote migration, adhesion and activation of leucocytes through the release of different factors such as SDF1/CXCL12 and VCAM1/ICAM1 (Komai-Koma et al, 2003; Volin & Koch, 2011). This evidence concerns the gene CXCL12 and rheumatoid arthritis.