IFNG and acute lymphoblastic leukemia: Moreover, IFN-γ plasma levels, an indication of IL-18 pathway activation (Okamura et al, 1995), were also significantly increased in patients with T-ALL (n = 25) compared to controls (n = 15; Fig 5D), and probably as a consequence also there was an increase in IL-18-binding protein (IL-18BP, Supplementary Fig S8; Dinarello et al, 2013).