Interestingly when looking into mouse IL-18 production either in tumour-free (Fig 5B) or in tumour-bearing (not shown) NSG mice, we found that haematopoietic CD45+ and non-haematopoietic CD45− cells could produce IL-18, suggesting that BM cells constitute a reservoir of IL-18 (Arend et al, 2008). Here, IL18 is linked to neoplasm.