CDKN1A and urinary bladder cancer: Our findings were further supported by inspection of TCGA exome sequencing data from 99 bladder cancers, which at the time of analysis in October 2013 showed two somatic SNVs in CDKN1A, one predicted to have strongly deleterious effects (p.Gly61Val, SIFT 0.00, Polyphen2 0.997) and the other to have possibly damaging effects (p.Asp136His, SIFT=0.11, Polphen2=0.553).