SETBP1 and chronic rhinosinusitis: Mice sensitized by intra-gastric gavage of ovalbumin (OVA) in the presence of SEB-containing sinus wash fluid from patients with chronic rhinosinusitis and then challenged with OVA, developed mucosal immunopathology in the colon, evidenced by marked degranulation of mast cells and eosinophils, infiltration of inflammatory cells, mucosal ulceration, and abscess formation in the lamina propria.