IFNL3 and Hepatitis: In the overall cohort we found no association between METAVIR histological activity of hepatitis and IL28B genotype distribution, and the same was true when patients were analyzed as single HCV-genotype category (Table 3), with the exception of more severe portal infiltrates in HCV-1 patients carrying the favorable IL28B CC genotype compared to other IL28B subgroups (CC vs. CT/TT: 86% vs. 63%, p = 0.005).