IFNL3 and chronic hepatitis C virus infection: The scrutiny of a large cohort of unselected patients infected with HCV genotype 1 to 4 who had a pretreatment liver biopsy available to assess necro-inflammation activity, fibrosis and steatosis in the liver, did not reveal any association between IL28B genotype and these histological features of chronic hepatitis C. This notwithstanding, in HCV-1 patients portal inflammation was to some extent associated to host genetic background, as the IL28B genotype CC emerged as an independent predictor of severe portal inflammation together with advanced patient age.