SREBF1 and hepatocellular carcinoma: Clinical association analysis by the Pearson chi-square test revealed that elevated SREBP-1 expression in HCC tissues was significantly associated with large tumor size (≥5 cm; p = 0.005, r = 0.413), high histological grade (Edmondson-Steiner grade III + IV; p = 0.006, r = 0.400) and advanced tumor stage (tumor-node-metastasis (TNM) stage III + IV; p = 0.010, r = 0.378) (Table 1).