A previous report has shown the association of RASSF1A with TNFR1 in the U2OS osteosarcoma cell line.20 However, it is not known whether RASSF1A binds to TRAF2 and TRADD and whether it links these molecules to TNFR1 following TNF-α stimulation. The gene discussed is TNF; the disease is osteosarcoma.